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Low IGF-1 may suggest: Growth hormone deficiency Chronic inflammation or illness Poor nutrition or malabsorption Low protein intake Chronic stress or elevated cortisol Liver disease High IGF-1 may suggest: Excess growth hormone (acromegaly) High protein/calorie intake Insulin resistance or high insulin levels Certain cancers or tumor risk (if sustained at high levels) Use of growth hormone therapy or certain peptides Optimal IGF-1 Levels While labs provide wide reference ranges, optimal levels are more specific when considering health, longevity, and performance goals

Because the DTC-PAC measure is a two-year measure, CY 2025 performance for the claims-based DTC-PAC measure will be calculated based on two years of performance data (CY 2024/2025) and compared to two years of baseline year data (CY 2022/2023)