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Ingredient-level evidence is mainly limited to in vitro, animal, or low-quality human studies, with only minor support for caffeine and adenosine in improving shedding or hair thickness

Due to untimely diagnosis, a significant number of children with GDH-HI displayed neurological sequelae, including mental retardation, cognitive impairment, learning disability, and social disorder [38]

Most of the compared enzymes contain two conserved domains: the FAD-binding domain (Pfam Id: 01565) at the N-terminus and an ALO catalytic domain (Pfam Id: 04030) at the C-terminus [84,108]

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