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Before you interpret this as evidence that bupropion hinders tirzepatide effectiveness, consider the confounders

The safety margin is enormous

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Addressing Brain Fog and Cognitive Dysfunction For patients experiencing significant brain fog and feeling like their brains not working properly, we often incorporate neurological support peptides: Semax A neuropeptide that enhances cognitive function, improves focus and mental clarity, and helps resolve brain fog by supporting neurotransmitter function and neuroplasticity

There is no control group (patients receiving a placebo), no randomisation, and selection criteria may introduce bias