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"One-carbon metabolism and nucleotide biosynthesis as attractive targets for anticancer therapy." Oncotarget 8.14 (2017): 23955
The mechanism involves an initial phase of acute hypoxia (ischemia) due to disrupted blood circulation, followed by a second phase of reperfusion injury when blood flow is restored, which exacerbates tissue damage (268)
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As an essential cofactor in PARP1/2-catalyzed processes, NAD+ plays a crucial regulatory function during DNA synthesis and repair
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