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Histamine 2/3 receptor agonists inhibit microglial activation and alleviate perioperative neurocognitive disorders in aged rats [66]

Notably, Akkermansia also promote L-aspartic acid transport from the gut to the liver by upregulating L-aspartate transporter ( Slc1a1 or Slc1a2 ) expression, thus activating the liver kinase B1 (LKB1)-AMPK axis to inhibit lipid oxidation in HFHCD-induced MASLD mice model [87]

Each production batch undergoes comprehensive testing, including dissolution rate analysis, impurity profiling, and active ingredient content verification using High-Performance Liquid Chromatography (HPLC) and UV spectrophotometry

Furthermore, in the subgroups of the severity of the liver injury, we found a significant difference between the two groups in terms of mild DILI ( P = 0.03), which was the most frequent type of liver injury in ours as previous studies (24, 27)