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Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl: PI3K and Nrf2-derived induction of antioxidative proteins

209,227,228,230241 MD simulations show that (1) while dewetting does happen in the melittin tetramer protein, 225 (2) it does not happen in the two-domain protein BphC, 223,224 and (3) the dewetting phenomenon can disappear in the presence of small additional interactions, and depends on force field parameters

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Noh JW, Jun MS, Yang HK, Lee BC

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