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When we compared the enzymatic activity of both purified recombinant proteins, we observed that GpoA Cys36Ala -His x6 lost the glutathione peroxidase capacity compared with GpoA wt -His x6 (Fig 4B)

A narrower mechanism usually means fewer off-target signals to interpret

It gives the joint fluid its viscous, slippery quality enabling reduced joint friction and weight-bearing activity

J Am Chem Soc 95:27972803 Requejo R, Hurd TR, Costa NJ, Murphy MP (2010) Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage

doi: 10.4155/fmc.15.161
