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80 When there is a reduction in liver GSH or increased concentrations of GSSG by toxin or disease, a vicious cycle might start

an anticoagulant preferably selected form the group consisting of heparin, ethylenediaminetetraacetate (EDTA), citrate and fluoride, preferably heparin or EDTA, or further comprising a coagulant preferably micronized silica particles or thrombin

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QSSA was used in this iteration of the design to assume enzyme levels stayed constant, but further investigation of the induction of oxidative stress genes by ROS and how this might change enzyme concentrations would be of value