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However, decades of clinical experience and mechanistic studies have revealed their inherent limitations, including broad immunosuppression, cumulative toxicity, and delayed tissue repair [318, 319]

In combination with immunological cross-reactivities and functional data they formed the basis of an evolutionary tree (Figure 1 shows a phylogram based on the aminoacid sequences of the 18 distinct gene products occurring as soluble dimeric proteins in humans

In order to examine how was the behavior when considering our complete population sample, we analyzed the data exhibited in the following figures and table

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