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Stained slides were analyzed using Qu-Path digital imagining analysis to measure staining intensity as previously described (Lee et al., 2020)
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10.1111/j.1438-8677.2012.00585.x 8 BakerC
In individuals with primary coenzyme Q 10 deficiency, early treatment with high-dose coenzyme Q 10 supplementation (1030 mg/kg/day in children and 1.23.0 g/day in adults) may improve the pathological phenotype, yet the effectiveness depends on the type of mutations affecting the coenzyme Q 10 biosynthetic pathway (1, 26)
It is believed that as many as 60% of the UK population have lower than the recommended levels
