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The appearance of drusen, typically following the formation of BLamD, further disrupts RPE organization, placing both mechanical and physiological stress on the surrounding RPE cells, which results in cell death [29]

Faseb j 37(7):e23018 Hill BG et al (2019) Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine
Anatomy and histology of the eye and orbit in domestic animals

Nova publishers, New York, pp 155185 Queiroz C, Mendes-Lopes ML, Fialho E, Valente-Mesquita VL (2008) Polyphenol oxidase: characteristics and mechanisms of browning control

They also found more Treg cells in LNs invaded by melanoma cells Figure 2
