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5e) and hepatic expression of DNL-related genes, stellate cell activation genes and fibrogenesis-related genes ( Timp1 ) were also reduced (Extended Data Fig
These toxicities can affect nearly any organ system but most commonly manifest as dermatologic toxicity, endocrinopathies, and severe autoimmune colitis , which requires prompt recognition and management with systemic corticosteroids
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I mean, that was the, the impetus of the whole thing
