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Acute glycolytic flux generates lactate that acidifies the microenvironment, proton loads inactivating sirtuin deacetylases to impair peroxisome proliferator-activated receptor gamma coactivator 1 alpha-mediated mitochondrial biogenesis [71] while activating calcium-independent phospholipase A 2 to liberate arachidonic acid [72]

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doi: 10.1139/cjpp-2015-0305
