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These functional protective effects are consistent with metaproteomic findings in children with recent-onset T1D (188), where gut microbiota dysregulation (including reduced butyrate-producing taxa) correlates with -cell damage severity, supporting a clinical link between butyrate deficiency and T1D pathogenesis

Several theories have proposed pathophysiological commonalities, but the data are conflicting

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doi: 10.3390/molecules191119066

The 8mg dose achieved 22.8% reduction, and even the 4mg dose reached 21.1%