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237 detected metabolic responses related to perturbations in glutamine metabolism in 47 independent breast cancer-derived cell lines, meaning that the inhibition of xCT promotes an adjustment in glutamine metabolism, which indirectly contributes to the import of cysteine through the exchange with glutamine-derived glutamate through xCT
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Moreover, the IGF-1R pathway and its associated Akt pathway, linked to KDM5A and H3K4 targets, are also modulated in DTP cells
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