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The other is it can break down in stomach acid, requiring the body to put it back together (which is nutrient intensive)
While this hasn't been clinically validated for injectable use, the biochemistry supports it
& Neuhaus, J
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GLP-1 carries most of the appetite effect, glucagon drives much of the liver- and visceral-fat loss, and GIP improves insulin handling while buffering some GLP-1-related nausea
