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Moreover, Parkin plays a role in regulating microglial and astrocyte activation (151, 152), processes that are deeply intertwined with neuroinflammation and oxidative stress, both of which can influence ferroptosis susceptibility in PD

If levels are low, it can impact everything from the mood to the metabolism

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453,457 Several studies have shown that in different adipocyte models, such as primary adipocytes, 3T3-L1 preadipocyte cell and SGBS cell, NAMPT can be secreted directly into the supernatant through non-classical pathways

Int Rev Cell Mol Biol 2022;373:159-97