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Caspase-3 is often described as an executioner enzyme in the programmed cell death pathway, because once it becomes activated and cleaved, it appears to orchestrate the dismantling of the cell through the proteolytic breakdown of essential structural and regulatory proteins

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There have been postmarketing reports of acute renal failure (unspecified) and worsening of chronic renal failure, which sometimes has required hemodialysis in patients treated with GLP-1 receptor agonists

[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Sanchez, L., Wang, Y., Siegel, D