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Materials and Methods The study was a randomized, double-blind, placebo-controlled trial (registered at clinicaltrials.gov as NCT00641862)

In a 2-year trial involving patients with type 2 diabetes mellitus (T2DM) and high cardiovascular risk, more events of diabetic retinopathy complications occurred in patients treated with semaglutide 0.5 and 1 mg once weekly injections (3%) compared to placebo (1.8%)
The biggest cons of semaglutide for her are: Nausea Hyper-fixating on foods Receiving some backlash for taking the medication The nausea was "awful," Dunham said: "Not unmanageable, but not fun." By "hyper-fixating" on foods, Dunham means that if she feels she wants, say, McDonald's French fries, she's not satisfied and doesn't want to eat anything else until she's got them, she said

This timeline allows the body to adapt to improved NAD+ availability and mitochondrial function
