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Scratch-wound assays mainly evaluate two-dimensional closure across a culture surface and are sensitive to wound width, cell confluence, proliferation rate, matrix coating, and serum concentration

But pramlintide has a short half-life, requiring users to inject it before every meal

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Another approach of TNF- pathway blockade that has been recently examined is the development of orally active small molecules (such as UCB-9260) that destabilize TNF- trimer, impeding TNF--TNFR1 binding and signaling [200]