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The GOAL study: a prospective examination of the impact of factor V Leiden and ABO(H) blood groups on haemorrhagic and thrombotic pregnancy outcomes

35 This fusion causes alterations in the actin cytoskeleton that promote the motility of chronic myeloid leukaemia cells, as demonstrated in various cell lines in vitro

Nonetheless, the aforementioned animal models, although extremely useful in investigating specific molecular mechanisms in the pathogenesis of ulcerative colitis, do not truly recapitulate disease as observed in patients, as IBD is a multifactorial disease and most clearly is not caused by a single mutation or defect in cellular or molecular pathways

Inconsistent use diminishes its effect on craving regulation

Inhibitors of ROS production have the potential of specificity, as drugs can be designed to inhibit specific ROS-generating systems