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The oxidative state of the proteins was analyzed by immunoblotting using the primary anti-FLAG Tag (9A3) mouse mAb (Cell Signaling Technology, cat

Progressive decline of glucocerebrosidase in aging and Parkinsons disease

doi: 10.1016/j.rmed.2013.08.008

Cofactor for L-methylmalonyl-coenzyme A mutase 5-Deoxyadenosylcobalamin is required by the enzyme that catalyzes the conversion of L-methylmalonyl-coenzyme A to succinyl-coenzyme A (succinyl-CoA), which then enters the citric acid cycle ( Figure 2 )

The disease typically presents between ages 5-35 years, but manifestations can occur earlier in life or as late as 70 years, when symptoms become apparent due to significant copper accumulation over time without appropriate treatment measures taken during earlier life stages