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Revista Brasileira de Cincia Avcola, 13, 147152

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By contrast, cell therapy products, particularly MSCs, operate through multiple simultaneous mechanisms including: (i) immunomodulation via secretion of anti-inflammatory cytokines (IL-10), transforming growth factor-beta (TGF-), IL-1 receptor antagonist (IL-1Ra), and attenuation of pro-inflammatory mediators (TNF-, IL-1, IL-6, matrix metalloproteinase 13 (MMP13), a disintegrin and metalloproteinase with thrombospondin motifs 4/5 (ADAMTS4/5)) 22,23,24