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Lipids were further filtered by retention time and confirmed by a fragmentation mass spectrum
What molecular mechanism does Dihexa (N-Hexanoic-Tyr-Ile-(6) aminohexanoic amide) target in the brain? Dihexa binds hepatocyte growth factor (HGF) receptors (c-Met) on neuronal surfaces with three-fold higher affinity than endogenous HGF, triggering PI3K/Akt signaling that upregulates brain-derived neurotrophic factor (BDNF) gene expression
Cell Stem Cell, 3, 649657
[DOI] [PMC free article] [PubMed] [Google Scholar] Han C
All safety data extrapolates from individual peptide studies conducted primarily in animals
