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In addition, in vitro experiments involving the stimulation of human retinal endothelial cells and HUVECs with recombinant ESM1 demonstrated the activation of MAPK (ERK, JNK and p38) signaling pathways associated with angiogenesis (47,58), which further confirms the relationship between ESM1 and the MAPK signaling pathway

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Experimental data indicates that the peptide fragment interacts with the 3-adrenergic pathway, which mediates the breakdown of triglycerides into free fatty acids and glycerol within adipose tissue

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