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Clinical studies show that AKK levels are markedly reduced in metabolic diseases such as obesity and non-alcoholic fatty liver disease, where its depletion correlates inversely with markers of oxidative damage (Xu et al., 2020)

These include patients with pernicious anaemia, an autoimmune condition where the body attacks cells in the stomach that produce a protein called intrinsic factor, which helps it absorb B12

Importantly, complementation of the ceg14 strain with ceg14 but not with the ceg14 H/A mutant restored the mutants ability to reduce cellular ATP levels during infection (Fig

& Jain, R

Environmental Health and Toxicology