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This interaction between PD-L1 and PD-1 is known as an immune checkpoint pathway and serves as the target for immune checkpoint inhibitors 45
So now he's in an environment where he's being exposed to a chronic issue, and he has a predisposition to not be resilient to that issue
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For instance, the free intracellular Cu during the transition between the Cu + and Cu 2+ states can produce hydroxyl radicals, namely, reactive oxygen species (ROS) [8]
