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However, during pyrimidine biosynthesis, a 1C unit is used in methylation reactions using methylene-tetrahydrofolate (methylene-THF) as the methyl donor, where deoxyuridine monophosphate (dUMP) is converted to deoxythymidine monophosphate (dTMP) with the help of thymidylate synthase (TYMS) [53]

[99] Overdose [edit] Clomipramine overdose usually presents with the following symptoms: [19] [21] [22] Signs of central nervous system depression such as: stupor coma drowsiness restlessness ataxia Mydriasis Convulsions Enhanced reflexes Muscle rigidity Athetoid and choreoathetoid movements Serotonin syndrome - a condition with many of the same symptoms as neuroleptic malignant syndrome but has a significantly more rapid onset Cardiovascular effects including: arrhythmias (including Torsades de pointes) tachycardia QTc interval prolongation conduction disorders hypotension shock heart failure cardiac arrest Apnoea Cyanosis Respiratory depression Vomiting Fever Sweating Oliguria Anuria There is no specific antidote for overdose and all treatment is purely supportive and symptomatic

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At a glance Origin: Gastric peptide

10.1371/journal.pone.0016360 PLoS One 18 DixonD