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IVIg also provides sustained benefit in 67% of patients over a median 3.3 (1 to 18)-year period, but in 29%, the benefits are diminishing after a mean 3.3-year period due to disease progression (17), highlighting the need for more effective long-term therapies

More High glucose increased ROS (reactive oxygen species) generation in endothelial cells

Kakogiannos N, Ferrari L, Giampietro C, Scalise AA, Maderna C, Rav M, Taddei A, Lampugnani MG, Pisati F, Malinverno M, et al

Annals of the New York Academy of Sciences 89 (1), 102108.(1960) 13

Common structural features of MAPEG a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism