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The search focused on human studies published over the last four decades, prioritising randomised controlled trials (RCTs) and meta-analyses to ensure strong clinical evidence

5 Fentanyl Is Widening Grip on the Nation as Western Presence and Detection with Other Drugs Increase to Record Highs, Millennium Health Signals Report 317 843 Millennium Health Millennium Health2023-02-21 04:50:282025-04-17 15:34:12 Signals Report Vol

That is a very different evidence class than an FDA-approved drug carrying settled phase-three data, and the difference is clinically meaningful rather than a technicality

This is what the mechanistic description and variant should be based on ARG treated as a form that may change stability or formulation parameters, but requires separate validation
