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Description

S.FormanS

GPXs GPXs, discovered in 1957, comprise an enzyme family with eight members (GPX1-GPX8) characterized by similar sequences, biochemical functions and a catalytic domain consisting of selenocysteine/cysteine, glutamine and tryptophan [10,11]

Favism in children can be fatal if not promptly treated, and rasburicase, potentially a lifesaver in a patient with an incumbent tumor lysis syndrome, can become a serious hazard if the patient happens to be G6PD deficient (Figure 7B)a typical example of a pharmacogenetic hazard

Supplementary Table 4 (download XLSX iSim_A (A value derived from iSim approach of one to another drug) / iSim_CsIte (CsIte value derived from iSim approach of one to another drug) / iSim_Cs (Cs value derived from iSim approach of one to another drug) / iSim_Ps (Ps value derived from iSim approach of one to another drug) / MutualInformation (Similarity value of one to another drug derived from mutual information) / SpearmanCorrelation (Similarity value of one to another drug derived from Spearman correlation) / Chemical similarity (Chemical similarity (based on SMILES codes) derived from Tanimoto distance analysis)