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Additionally, it is beneficial as a combination therapy in improving the outcome of gliomas [115]

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Lactate produced through astrocytic aerobic glycolysis is then shuttled to neurons where it is used to produce energy in the mitochondria, i.e., lactate is converted to pyruvate which is then processed in the tricarboxylic acid (TCA) cycle, hence bypassing neuronal glycolysis (Magistretti, 2009

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