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In addition to the behavioral impairment autism is associated with a high incidence of gastrointestinal disease and dysbiosis, autoimmune disease and mental retardation

These conditions (notably the incubation temperature of 22 C, rather than 37 C used for expression of most proteins) are specifically optimised for expression of N-terminal fragments of IP 3 R

Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action

Due to its targeted interaction with NNMT, 5-Amino-1MQ serves as a valuable research tool for studying metabolic enzyme activity and peptide-independent regulatory mechanisms

doi:10.1016/j.pharmthera.2009.07.003 Purves D, Augustine GJ, Fitzpatrick D, et al