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10.1002/hep.510230521

Rhein treatment could significantly reduce the level of uric acid, which plays a detrimental role in the integrity of the intestinal barrier

The side effect profile is similar to those of the component medications and includes conjunctival hyperemia (63%), instillation site pain (23%), conjunctival hemorrhage (13%) and verticillata (17.6%)

2017 Jul;24(4):393-401

For example, lncRNA SNHG29 boosts PD-L1 expression by activating YAP, while LINC00460 acts as a molecular adsorbent for miR-186-3p, which results in an elevation for MYC, CD47, and PD-L1, consequently strengthening immune evasion in CRC cells