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As a central energy sensor, AMPK extends lifespan by promoting autophagy via mTOR inhibition and ULK1 activation, enhancing mitochondrial function through PGC-1/SIRT1 signaling and improving the NAD + /NADH balance, suppressing inflammatory responses via NF-B inhibition, and modulating stress resistance via the FOXO3/p53 pathways, thereby linking metabolic regulation to aging suppression 41

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These mice did not continue to the probe or reversal phase

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(Archived 7/24/2017) A: While the hospital needs assessment can be a good starting point for the community assessment, it will not likely be sufficient

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