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For determining chronic exposure levels, plasma was obtained 48 h following dose 24 of vehicle or L2-Cmu by i.p

These are consistent with the increased expression of the transcriptional coactivator peroxisome proliferator-activated receptor-coactivator 1 (PGC-1) observed in SNc neurons (Pacelli et al., 2015)

Chung, J.-O., Lee, S.-B., Jeong, K.-H., Song, J.-H., Kim, S.-K., Joo, K.-M., Jeong, H.-W., Choi, J.-K., Kim, J.-K., Kim, W.-G., Shin, S.-S., & Shim, S.-M

2.2 Chemicals and reagents Natural phytocannabinoids, including cannabichromene (CBC), cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN), cannabicitran (CBT), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabigerolic acid (CBGA), and delta-8-tetrahydrocannabinol (8-THC), were purchased from Cayman Chemical (Ann Arbor, MI, United States)

46 Of note, increasing lncExACT1 induced pathological hypertrophy, while reducing lncExACT1 induced physiological hypertrophy phenotypes seen with exercise training (myocardial hypertrophy, increased proliferation markers of cardiomyocytes) and improved cardiac function in vivo