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"Oral Collagen Supplementation: A Systematic Review of Dermatological Applications." Journal of Drugs in Dermatology, vol

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According to the paper, which was published in Science Translational Medicine, one of the clear-skinned participants ending up developing acne one week after recieving the vitamin B12 injection

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For B12 deficiency, a typical injection dose is 1,000 mcg once a week for 4 to 8 weeks and then 1,000 mcg once a month