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Trefoil factor 3 (TFF3) from human breast milk activates PAR-2 receptors, of the intestinal epithelial cells HT-29, regulating cytokines and defensins

Introduction Macroautophagy is a promising new target for cancer treatment as this cellular pathway has both cancer-suppressing and cancer-promoting mechanisms

Urol Oncol, 7: 223-227, 2002

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To test this, we generated a chimera by replacing the cytosolic tail of the plasma membrane protein interleukin-2 receptor alpha chain (IL-2R) with the C-terminal tail of LYSET (amino acids 88131) (Fig