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While little is known on the sex differences in MTHFR polymorphisms, sex hormones, such as estrogen is known to play a protective effect in female patients with schizophrenia as for the impact of neurodevelopment and social maturation 55

Neutrophilic inflammation occurs in both lung and GCF, where activating cytokines are produced by the underlying fibroblasts, lining the epithelium and inflammatory cells in response to microbial insult

Although mouse [22, 23] and fly [24] models with mutations in Gdap1 have reproduced several traits found in human CMT disease, the precise function of GDAP1 in healthy settings and its mechanistic link to CMT disease remains uncertain [25,26,27,28]

Children and pregnant or lactating women should consult their healthcare practitioner prior to use

R01DK123358 to C.B.P