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Feb 2020;9(4):1495-1502
GPX4 inhibition with RSL3 induces ferroptosis, lipid peroxidation and reactive oxygen species (ROS) in thyroid cancer cells in vitro We targeted the ferroptosis pathway in PTC cells in vitro using a pharmacologic inhibitor of GPX4, RSL3
Tumor tissues from patients whose cells were successfully expanded showed enhanced Ki-67 expression and reduced apoptotic activity compared to matched normal tissues, indicating a proliferative, apoptosis-resistant phenotype (Supplementary Fig
Lippi et al., 2012)
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