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The molecular mechanisms of copper metabolism and its roles in human diseases

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In vivo , the oxidized form of LA can be rapidly reduced to dihydrolipoic acid (DHLA) in a nicotinamide adenine dinucleotide (NADH)-dependent manner by dihydro-lipoamide dehydrogenase in mitochondria [23]

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278 In the face of this challenge, anti-DTP therapy may be recognized as crucial in reducing the emergence of such drug resistance, thereby becoming a necessary intervention