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It remains reserved for severe cases unresponsive to medical management

Women typically start with 50mg daily and may progress to 75mg if well-tolerated

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24, 39, 40, 268, 269 A key issue for future clinical trial design will be to identify clinically relevant objective criteria for patient enrollment, and this remains a challenge, which has delayed a more aggressive approach of the pharmaceutical industry to identifying new treatment avenues for this condition

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