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doi: 10.1016/j.bioactmat.2022.04.021

A similar finding was observed in a study of Nrf2 activation in the heart, which showed that upregulation of the pentose phosphate pathway can improve cardiac function by reducing oxidative stress and supporting metabolic reprogramming [274]

1 illustrates the essential reactions and feedback mechanisms among ROS, GSH, GSSG, NADPH and G6P in the outer retina, which we focus on and model as a system of ordinary differential equations (ODEs), where all parameters are non-negative

Some of which were clinically ineffective despite being formerly effective in pre-clinical studies

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