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However, in the last decade the pharmacological mechanism of APAP as a cannabinoid system modulator has been documented and some articles have reported in situ toxicity by APAP in brain tissue at high doses

Blokhuis AM, Groen EJN, Koppers M et al (2013) Protein aggregation in amyotrophic lateral sclerosis

10.1016/j.bbadis.2025.167693 Biochim Biophys Acta Mol Basis Dis

S., Borja, J

& Mitchell S
