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The equine EcaGST A3-3 and HsaGST A3-3 display k cat /K m values of 1.6 10 7 and 8.6 10 6 M 1 s 1 , respectively (Lindstrm et al., 2018) ranking them among the enzymes with particularly high activity (Wolfenden and Snider, 2001), even though the bacterial ketosteroid isomerase has an even higher catalytic efficiency of approximately 4 10 8 M 1 s 1 ( 8 -10 9 M 1 s 1 )

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These effects could potentially mitigate age-related cardiac decline and support overall heart health, though further studies are needed to confirm these benefits in humans

As in mammals, zebrafish have TR and TR receptors

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