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Additionally, mitochondrial DNA mutations and reduced mitophagy exacerbate mitochondrial dysfunction and contribute to the progression of AD [158]

FIGURE 2 3 Redox dysregulation in disease states 3.1 GSH in peripheral immune cell infiltration Several studies indicate that neuroinflammatory changes associated with neurodegeneration compromise the BBB or its function by disrupting transport systems, facilitating the infiltration of immune cells, and influencing the BBBs role as a signaling interface

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doi: 10.1038/nature14319 110 AlessioNRiccitielloFSquillaroTCapassoSDel GaudioSDi BernardoGet al

AmreinKParekhDWestphalSPreiserJBergholdARiedlRet alEffect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a study protocol of a multicentre, placebo-controlled double-blind phase III RCT (the VITDALIZE study)