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It is also used to treat pernicious anemia, vitamin B 12 deficiency (due to low intake from food or inability to absorb due to genetic or other factors), thyrotoxicosis, hemorrhage, malignancy, liver disease and kidney disease

By employing this innovative protocol, we were able to minimize potential interferences arising from proteins, amino acids, or sugars that could have affected the accuracy of the GPx activity measurements

J C van Wyk II

For finer staging and detection of steatohepatitis, disease activity, or early fibrosis, markers such as cytokeratin-18 (CK-18), N-terminal propeptide of collagen type 3 (PRO-C3), and omics-based profiles (transcriptomic or lipidomic) can be used [74, 75]

Overall, although six decades-long, this multiplex field of research is still dynamic and subject to evolve due to acquiring deeper insights and new knowledge of this intricate network of molecules and their reactions