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Vitamin B12 deficiency nerve damage may be relevant

Appetite suppression is the standout effect

The time when you will notice significant changes in response to B12 supplementation is when you ask how long B12 takes to work

Vitamin B12 deficiency has been linked to fatigue, tingling or loss of feeling in the extremities, irritability, memory impairment, depression, anemia, irritable bowel syndrome (IBS), constipation, poor wound healing, dry or damaged looking skin, and neurological disorders

All outcomes were continuous, and the relative treatment effects were pooled as mean difference (MD) with 95% confidence intervals