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This upregulation of CYP2E1 explains, in part, the metabolic tolerance to alcohol and the cross-tolerance to other drugs that are also substrates of CYP2E1, such as pentobarbital and diazepam, in people with AUD (90)
Colonic bacteria ferment fiber and metabolize bile acids
Insufficient B12 levels can lead to neural tube defects in the developing fetus
Shi J, Gao W, Shao F
