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Tolerance and physical dependence may develop, and withdrawal symptoms (fatigue, depression) can follow abrupt cessation after high-dose or prolonged use

Annu Rev Neurosci 15:129 Liu S, Zhang P, Ji X, Johnson WW, Gilliland GL, Armstrong RN (1992) Contribution of tyrosine 6 to the catalytic mechanism of isoenzyme 33 of glutathione S-transferase

[] Glutathione, often referred to as the master antioxidant, plays a vital role in cellular health and detoxification

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For example, some medications can reduce the bodys ability to produce glutathione, making it more challenging to absorb supplements